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Cardiovascular Disease: A High-Volume, High-Impact Growth Opportunity in the Small Interfering Rna Market
The application of siRNA technology in Cardiovascular Disease (CVD), particularly for conditions like hypercholesterolemia, represents the largest potential high-volume opportunity segment within the Small Interfering Rna Market.
Drugs like inclisiran (Leqvio) target and silence the PCSK9 gene, which plays a major role in regulating low-density lipoprotein cholesterol (LDL-C) levels. By silencing PCSK9, the drug dramatically and sustainably reduces harmful cholesterol with only two doses per year.
This approach offers a fundamentally new treatment modality for millions of patients with high cholesterol who are intolerant of or unresponsive to standard statin therapy. Because CVD is a massive public health issue, the success of inclisiran is paving the way for further large-scale investments in siRNA therapies targeting other widespread chronic conditions, securing the enormous potential of this segment in the Small Interfering Rna Market.
FAQ
Q: What key protein does the siRNA drug inclisiran target to lower cholesterol? A: Inclisiran targets the messenger RNA (mRNA) for the PCSK9 protein, silencing its expression and thereby enhancing the liver's ability to clear LDL cholesterol from the blood.
Q: Why is cardiovascular disease considered the high-volume growth driver compared to rare diseases? A: CVD is one of the most prevalent chronic conditions globally, offering a patient population many orders of magnitude larger than that for any single rare genetic disorder.
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